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The crash was reported at approximately 3:50 a.m. on Friday, May 12 in the 6300 block of Oxon Hill Road.
Officials say that one man - who has not been identified by police - was treated and rushed to an area hospital with life threatening injuries.
He was later pronounced dead, according to police.
The crash led to a shutdown of Oxon Hill Road in both directions for several hours as officers investigated the incident.
It is unclear what caused the crash.
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